Samantha Who? – a short-lived TV series starring Christina Applegate. Running for two seasons before being cancelled in July 2009, Samantha Who? was a TV series about a woman who was stricken with amnesia and set about to become a better person than she had apparently been before the affliction. Not an unsuccessful show, it actually started off with excellent ratings in the United States, being the most-watched sitcom there for more than a month. However, interest fell, and ABC cancelled it after 35 episodes.